HIF
HIF (Hypoxia-inducible factors) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.Hypoxia often keeps cells from differentiating. However, hypoxia promotes the formation of blood vessels, and is important for the formation of a vascular system in embryos, and cancer tumors. The hypoxia in wounds also promotes the migration of keratinocytes and the restoration of the epithelium.
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IOX2是低氧诱导因子（HIF）脯氨酰羟化酶（PHD）抑制剂，在细胞中对PHD2/ELGN-1的IC50为21 nM，对FIH无活性。
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2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。
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PX-478是缺氧诱导因子1a的抑制剂, IC50值为20-30uM, 可提高前列腺癌细胞的辐射敏感性。
More
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IOX2是低氧诱导因子（HIF）脯氨酰羟化酶（PHD）抑制剂，在细胞中对PHD2/ELGN-1的IC50为21 nM，对FIH无活性。
More
-
2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。
More
-
PX-478是缺氧诱导因子1a的抑制剂, IC50值为20-30uM, 可提高前列腺癌细胞的辐射敏感性。
More
